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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are often characterized by a focus on practical aspects of the research design, like the recruitment process and consent in adherence, as well as the use of routinely available equipment.

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A pragmatic study that involves various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for pragmatic trials to be valid, 프라그마틱 카지노 and it also helps reduce bias in the results. Too much heterogeneity, however, can cause problems with the design of the trial.

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The goal of pragmatic trials is to replicate real-life scenarios and gain maximum validity externally. They are typically commissioned by policymakers and practitioners to help guide their decisions. They can also be used to assess the cause-effect relationship of an intervention and its effects. However, they shouldn't be used in lieu for explanation trials.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory tests or if they should serve as a complement to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform policy and practice decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic research study which includes the recruitment, design, and delivery of the intervention and its follow-up.

There is a growing increase in the number of pragmatic trials published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.