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It has been recognized as one of the top gaming platforms for casinos despite its relative infancy. The most recent releases include Wolves 5 reel video slot with a healthy RTP and impressive graphics. The other notable titles include Wolf Gold and Chilli Heat.<br><br>Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically commissioned by practitioners and policy makers to guide their decision-making. They can also be used to determine the causality of an intervention and its effects. However, they should not, be used to replace the need for explanation studies.<br><br>The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace explanatory tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which prove the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform the practice and policy decision-making. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool sought to define the elements of a practical trial, including the recruitment process, the design and delivery of the intervention, as well as follow-up.<br><br>The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) resulted in 34 articles, as shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of these trials were conducted in primary care settings.
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